Chloramphenicol acetyltransferase



Chloramphenicol acetyltransferase (CAT) is an enzyme which make bacteria resistant to chloramphenicol. It attaches acetyl from acetyl-CoA to chloramphenicol thus preventing it from binding to the ribosome. The images at the left and at the right correspond to one representative CAT, i.e. the crystal structure of Chloramphenicol acetyltransferase from Vibrio cholerae (3eev).

3D Structures of Chloramphenicol acetyltransferase
3eev – CAT – Vibrio cholerae

2i9d – CAT – Bacteroides thetaiotamicron

Chloramphenicol acetyltransferase I
1pd5, 1cia - EcCAT I – Escherichia coli

1q23 – EcCAT I + fusidic acid

1noc - EcCAT I + inducible nitric oxide synthase oxygenase domain

Chloramphenicol acetyltransferase III
(See also: Chloramphenicol Acetyltransferase Type III‎)

4cla, 3cla, 1cla – EcCAT III

2cla - EcCAT III (mutant)

1qca – CAT III (mutant) + fusidic acid – Shigella flexneri